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Invitrogen
LHR Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-76197
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein of human LHCGR.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
LHCGR encodes the receptor for both luteinizing hormone and choriogonadotropin. It is family 1 of G-protein coupled receptors, FSH/LSH/TSH superfamily, and its basic function is acting as luteinizing hormone/choriogonadotropin receptor (gonadotropin receptor). Regulating the development and function of Leyding cells in males. It also plays a role in male secondary sexual characterdevelopment. Mutations in this gonadotropinreceptor results in disorders of male secondary sexual characteristic development, such as familial male precocious puperty and male pseudohermaphtoditism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HCG receptor; LH receptor; LH/CG-R; LHR; LSH-R; Luteinizing hormone receptor; Lutropin receptor; Lutropin-choriogonadotropic hormone receptor
基因别名: Gpcr19-rs1; LCGR; LGR2; LH-R; LH/CG-R; LHCGR; Lhr; LHRHR; LSH-R; LSHR
UniProt ID: (Rat) P16235, (Mouse) P30730
Entrez Gene ID: (Rat) 25477, (Mouse) 16867
luteinizing hormone receptor activity
G-protein coupled peptide receptor activity
peptide hormone binding
choriogonadotropin hormone receptor activity
choriogonadotropin hormone binding
identical protein binding
protein homodimerization activity
ATPase binding
signal transducer activity
G-protein coupled receptor activity
protein-hormone receptor activity
G-protein coupled receptor
ovarian follicle development
protein targeting to lysosome
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
spermatogenesis
central nervous system development
male gonad development
female gonad development
hormone-mediated signaling pathway
positive regulation of calcium ion transport into cytosol
ovulation cycle process
positive regulation of inositol trisphosphate biosynthetic process
response to drug
luteinizing hormone signaling pathway
positive regulation of cAMP-mediated signaling
development of secondary male sexual characteristics
positive regulation of hormone biosynthetic process
arachidonic acid secretion
regulation of steroid biosynthetic process
positive regulation of calcium-mediated signaling
cognition
positive regulation of release of sequestered calcium ion into cytosol
uterus development
cellular response to gonadotropin stimulus
seminiferous tubule development
regulation of steroid hormone biosynthetic process
signal transduction
adenylate cyclase-activating G-protein coupled receptor signaling pathway
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