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This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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This antibody is predicted to react with Monkey, Bovine, Pig.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with an approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer of lipid between HDL and cells. The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2; CD 36; CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II); CD36 antigen-like 2; CD36 molecule; LGP85; LIMP II; Lysosome membrane protein 2; Lysosome membrane protein II; Scavenger receptor class B member 2; scavenger receptor class B, member 2; sCD 36; sCD36; soluble CD 36; soluble CD36; SR-B2
基因别名: 9330185J12Rik; AMRF; CD36L2; EPM4; HLGP85; LGP85; LIMP-2; LIMP2; LIMPII; MLGP85; SCARB2; SR-BII
UniProt ID: (Human) Q14108, (Mouse) O35114
Entrez Gene ID: (Human) 950, (Mouse) 12492