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Invitrogen
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PA1-26497 detects LIS1 from human samples. PA1-26497 is expected to cross react with mouse, rat, chicken, bovine, porcine, and Xenopus laevis due to sequence homology.
PA1-26497 has been successfully used in Western blot procedures.
The PA1-26497 immunogen is a synthetic peptide corresponding to a portion of human Lissencephaly 1 (Lis 1) protein encoded inpart by exons 3 and 4.
VAMP7 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family, localizing to late endosomes and lysosomes. VAMP7 is thought to mediate the fusion of endosomes to their target lysosomes as well as other exocytosis events during phagocytosis and neuritogenesis. VAMP7 interacts with the VPS9 ankyrin repeat protein VARP, a protein that localizes to early endosomes and thought to regulate endosome dynamics. Together with CD82, VAMP7 can modulate the signaling of EGFR by regulating its endocytosis from the plasma membrane.
仅用于科研。不用于诊断过程。未经明确授权不得转售。