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Invitrogen
LKB1 Recombinant Rabbit Monoclonal Antibody (PSH09-29)
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LKB1 Antibody (MA562889) in IHC (P)
Immunohistochemical analysis of LKB1/STK11 was performed using formalin-fixed paraffin-embedded human testis tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - High pH (10X) (Product # 00-4956-58) diluted to 1X solution in water in a decloaking chamber at 110 degree Celsius for 15 minutes... View More
产品信息
MA562889
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH09-29
抗原
Recombinant protein within human LKB1 aa 1-400.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive Control: K-562 cell lysate, Jurkat cell lysate, HEK-293 cell lysate, COS-1 cell lysate, Mouse brain tissue lysate, Mouse testis tissue lysate, Rat testis tissue lysate, human testis tissue, mouse testis tissue, rat testis tissue.
Tissue Specificity: Low tissue specificity
Subcellular Location: Nucleus, Cytoplasm, Membrane, Mitochondrion.
Sequence Similarities: 92% Mouse/Rat
Predicted band size: 49 kDa.
靶标信息
LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11), a member of the serine/threonine kinase family, is a tumor suppressor. LKB1 physically associates with p53 and regulates specific p53 dependent apoptosis pathways. LKB1 is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. Mutations in LKB1 gene are associated with Peutz Jeghers syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CAMK group; CAMKL family; Liver kinase B1; Liver kinase B1 homolog; LKB 1; LKB-1; LKB1; LKB1(S); polarization-related protein LKB1; Renal carcinoma antigen NY-REN-19; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; Serine/threonine-protein kinase STK11
基因别名: AA408040; hLKB1; LKB1; Par-4; PJS; R75140; STK11
UniProt ID: (Human) Q15831, (Rat) D4AE59, (Mouse) Q9WTK7
Entrez Gene ID: (Human) 6794, (Rat) 314621, (Mouse) 20869
regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
autophagy
cellular response to DNA damage stimulus
cell cycle arrest
spermatid development
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
establishment of cell polarity
regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
response to glucagon
response to lipid
TCR signalosome assembly
glucose homeostasis
anoikis
response to peptide hormone
positive thymic T cell selection
positive regulation of gluconeogenesis
positive regulation of protein kinase activity
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of axonogenesis
T cell receptor signaling pathway
protein heterooligomerization
Golgi localization
regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to UV-B
intrinsic apoptotic signaling pathway by p53 class mediator
dendrite extension
positive regulation of protein localization to nucleus
positive regulation of autophagy
negative regulation of lipid biosynthetic process
positive regulation of protein serine/threonine kinase activity
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling
