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Proteintech
LMAN1 Polyclonal Antibody
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产品信息
13364-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ERGIC-53 Fusion Protein Ag4183 (35-401 aa encoded by BC032330)
偶联物
形式
Liquid
浓度
0.27 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: GDPAVALPH RRFEYKYSFK GPHLVQSDGT VPFWAHAGNA IPSSDQIRVA PSLKSQRGSV WTKTKAAFEN WEVEVTFRVT GRGRIGADGL AIWYAENQGL EGPVFGSADL WNGVGIFFDS FDNDGKKNNP AIVIIGNNGQ IHYDHQNDGA SQALASCQRD FRNKPYPVRA KITYYQNTLT VMINNGFTPD KNDYEFCAKV ENMIIPAQGH FGISAATGGL ADDHDVLSFL TFQLTEPGKE PPTPDKEISE KEKEKYQEEF EHFQQELDKK KEEFQKGHPD LQGQPAEEIF ESVGDRELRQ VFEGQNRIHL EIKQLNRQLD MILDEQRRYV SSLTEEISKR GAGMPGQHGQ ITQQELDTVV KTQHEILR (35-401 aa encoded by BC032330 )
靶标信息
The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: endoplasmic reticulum-golgi intermediate compartment protein 53; ER-Golgi intermediate compartment 53 kDa protein; Gp58; Intracellular mannose-specific lectin MR60; Lectin mannose-binding 1; lectin, mannose-binding, 1; p58; Protein ERGIC-53
基因别名: 2610020P13Rik; AI326273; AU043785; C730041J05; ERGIC-53; ERGIC53; F5F8D; FMFD1; gp58; LMAN1; MCFD1; MR60; P58
UniProt ID: (Human) P49257, (Mouse) Q9D0F3, (Rat) Q62902
Entrez Gene ID: (Human) 3998, (Mouse) 70361, (Rat) 116666
protein folding
ER to Golgi vesicle-mediated transport
endoplasmic reticulum organization
Golgi organization
blood coagulation
positive regulation of organelle organization
protein N-linked glycosylation via asparagine
protein exit from endoplasmic reticulum
early endosome to Golgi transport
COPII vesicle coating
transport
protein transport
vesicle-mediated transport
