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LNX2 Antibody (720004) in ICC/IF
Immunofluorescence was performed on fixed and permeabilized HCT 116 cells for detection of LNX2 using Anti-LNX2 Rabbit Polyclonal Antibody (Product # 720004, 3 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 0.4 µg/mL, 1:2500). Panel a) shows representative cells that were stained for detection and localization of LNX2 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938, 1:50). Panel... View More
产品信息
720004
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Multiple peptides against Human LNX2 (aa 442-458, 129-145, 671-683)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 30% glycerol, 0.1% BSA
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2532784
产品详细信息
This antibody is predicted to react with Goat, Bovine, Horse, Pig, Cat and Rabbit.
靶标信息
LNX2 (Ligand of Numb Protein X 2) protein is encoded by the LNX2 gene located on chromosome 13 in humans and is known as PDZRN1 (PDZ domain-containing RING finger 1). It is through its PDZ domains that LNX2 forms oligomers and interacts with some of its target proteins. LNX2 is best studied as a E3 ubiquitin ligase that also contains the NPXY motifs which allows binding to the Numb protein. This interaction has been shown to be responsible for ubiquitination of Numb, which prevents the proteasomal degradation of Notch intracellular domain (NICD) and thus modulates the Notch signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ligand of Numb protein X 2; Numb-binding protein 2; PDZ domain containing ring finger 1; PDZ domain-containing RING finger protein 1
基因别名: 9630046H24; AW209022; LNX2; PDZRN1
UniProt ID: (Human) Q8N448, (Mouse) Q91XL2
Entrez Gene ID: (Human) 222484, (Mouse) 140887, (Rat) 360761
