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Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MVLLERLRHP NVLQLYGYCY QDSEDIPDTL TTITELGAPV EMIQLLQTSW EDRFRICLSL GRLLHHLAHS PLGSVTLLDF RPRQFVLVDG ELKVTDLDDA RVEETPCAGS TDCILEFPAR NFTLPCSAQG WCEGMNEKRN LYNAYRFFFT YLLPHSAPPS LRPLLDSIVN ATGELAWGVD ETLAQLEKVL HLYRSGQYLQ NSTASSSTEY QCIPDSTIPQ EDYRCWPSYH HGSCLLSVFN LAEAVDVCES HAQCRAFVVT NQTTWTGRQL VFFKTGWSQV VPDPNKTTYV KASG
VLK was identified as a novel protein kinase that was induced after the differentiation of cultured embryonic stem cells into mesendoderm. It has no homologs in invertebrates, but is highly conserved in vertebrate species although it does not belong to any known protein kinase groups. VLK is initially expressed in E-cadherin-positive anterior visceral endoderm and mesendoderm, but its expression is later confined to E-cadherin-negative mesenchyme. It is enriched in the Golgi apparatus and is thought to regulate the rate of protein export from the Golgi. Targeted disruption of VLK in mice leads to a defect in lung development and neonatal lethality. It has been suggested that mutations in VLK may be associated with the allergic condition atopy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Extracellular tyrosine-protein kinase PKDCC; protein kinase domain containing, cytoplasmic homolog; Protein kinase domain-containing protein, cytoplasmic; Protein kinase-like protein SgK493; Sugen kinase 493; Vertebrate lonesome kinase
基因别名: PKDCC; SGK493; VLK
UniProt ID: (Human) Q504Y2
Entrez Gene ID: (Human) 91461