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Proteintech
LONP1 Monoclonal Antibody (1C6C12)
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产品信息
66043-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1C6C12
抗原
LONP1 Fusion Protein Ag7306 (614-959 aa encoded by BC000235)
偶联物
形式
Liquid
浓度
1.56 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: EQNANFLDH YLDVPVDLSK VLFICTANVT DTIPEPLRDR MEMINVSGYV AQEKLAIAER YLVPQARALC GLDESKAKLS SDVLTLLIKQ YCRESGVRNL QKQVEKVLRK SAYKIVSGEA ESVEVTPENL QDFVGKPVFT VERMYDVTPP GVVMGLAWTA MGGSTLFVET SLRRPQDKDA KGDKDGSLEV TGQLGEVMKE SARIAYTFAR AFLMQHAPAN DYLVTSHIHL HVPEGATPKD GPSAGCTIVT ALLSLAMGRP VRQNLAMTGE VSLTGKILPV GGIKEKTIAA KRAGVTCIVL PAENKKDFYD LAAFITEGLE VHFVEHYREI FDIAFPDEQA EALAVER (614-959 aa encoded by BC000235 )
靶标信息
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia. Alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: h LonHS; hLON ATP-dependent protease; Lon protease homolog, mitochondrial; lon protease homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03120}; Lon protease-like protein; lon protease-like protein {ECO:0000255|HAMAP-Rule:MF_03120}; LONHs; LONP; LONP {ECO:0000255|HAMAP-Rule:MF_03120}; LONP1; Mitochondrial ATP-dependent protease Lon; mitochondrial ATP-dependent protease Lon {ECO:0000255|HAMAP-Rule:MF_03120}; mitochondrial lon protease-like protein; protease, serine, 15; Serine protease 15; serine protease 15 {ECO:0000255|HAMAP-Rule:MF_03120}
基因别名: 1200017E13Rik; CODASS; hLON; LON; LonHS; LONP; LONP1; PIM1; PRSS15
UniProt ID: (Human) P36776, (Mouse) Q8CGK3, (Rat) Q924S5
Entrez Gene ID: (Human) 9361, (Mouse) 74142, (Rat) 170916
single-stranded DNA binding
single-stranded RNA binding
ATP-dependent peptidase activity
serine-type endopeptidase activity
protein binding
ATP binding
ADP binding
sequence-specific DNA binding
G-quadruplex DNA binding
DNA polymerase binding
mitochondrial light strand promoter anti-sense binding
mitochondrial heavy strand promoter anti-sense binding
mitochondrial light strand promoter sense binding
mitochondrial heavy strand promoter sense binding
nucleotide binding
DNA binding
peptidase activity
serine-type peptidase activity
hydrolase activity
ATPase activity
serine protease
mitochondrial genome maintenance
response to hypoxia
misfolded or incompletely synthesized protein catabolic process
mitochondrion organization
aging
response to hormone
response to aluminum ion
mitochondrial DNA metabolic process
cellular response to oxidative stress
chaperone-mediated protein complex assembly
protein homooligomerization
proteolysis involved in cellular protein catabolic process
oxidation-dependent protein catabolic process
regulation of mitochondrial DNA replication
proteolysis
protein catabolic process
cellular protein complex assembly
