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Invitrogen
LOX-1 Monoclonal Antibody (23C11), Biotin
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产品信息
MA5-49084
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
23C11
抗原
Fusion protein of extracellular domain (aa 71-273) of human LOX-1 with murine Fc-gamma1 (LOX-1-muFc) produced in PEAK cells
偶联物
形式
Liquid
浓度
100 µg/mL
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Monoclonal antibody 23C11 neutralizes LOX-1 and inhibits Hsp70 binding to dendritic cells and Hsp70-induced antigen cross-presentation. In vivo, targeting LOX-1 with a tumor antigen using anti-LOX-1 antibody 23C11 induces anti-tumor immunity.
靶标信息
LOX-1 (lectin-like oxidized LDL receptor -1) is a 40-50 kDa type II membrane glycoprotein class E scavenger receptor expressed by endothelial cells, macrophages, activated platelets and smooth muscle cells. LOX-1 binds to a wide range of ligands, including oxidized low-density lipoprotein (oxLDL), hypochlorite modified high-density lipoprotein (HDL), aged /apoptotic cells, activated platelets and bacteria, reflecting its versatile physiological functions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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