Invitrogen

LPIN1 Monoclonal Antibody (3D9)

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LPIN1 Antibody (MA5-21419) in WB

Western Blot analysis of LPIN1 expressed in transfected 293T cell line by anti-LPIN1 monoclonal antibody (Product # MA5-21419), clone 3D9. Lane 1: LPIN1 transfected lysate (Predicted MW: 98.7 KDa). Lane 2: Non-transfected lysate.

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产品信息

MA5-21419

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

酶联免疫吸附实验 (ELISA)

Assay-Dependent

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

3D9

抗原

LPIN1 (NP_663731.1, 792 a.a. ~ 890 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2-1.0 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2607832

产品详细信息

Peptide Sequence: EPFYAAFGNR PADVYSYKQV GVSLNRIFTV NPKGELVQEH AKTNISSYVR LCEVVDHVFP LLKRSHSSDF PCSDTFSNFT FWREPLPPFE NQDIHSASA

靶标信息

The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1A; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARA. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.

仅用于科研。不用于诊断过程。未经明确授权不得转售。