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Product Details
MA5-21419
产品规格
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3D9
Immunogen
LPIN1 (NP_663731.1, 792 a.a. ~ 890 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
形式
Liquid
浓度
0.2-1.0 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2607832
Product Specific Information
Peptide Sequence: EPFYAAFGNR PADVYSYKQV GVSLNRIFTV NPKGELVQEH AKTNISSYVR LCEVVDHVFP LLKRSHSSDF PCSDTFSNFT FWREPLPPFE NQDIHSASA
Target Information
The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1A; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARA. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: DKFZp781P1796; Lipin-1; Phosphatidate phosphatase LPIN1
Gene Aliases: KIAA0188; LPIN1; PAP1
UniProt ID: (Human) Q14693
Entrez Gene ID: (Human) 23175
transcription, DNA-templated
triglyceride mobilization
phosphatidylethanolamine biosynthetic process
phosphatidylcholine biosynthetic process
mitotic nuclear envelope disassembly
fatty acid catabolic process
dephosphorylation
triglyceride biosynthetic process
organ regeneration
cellular response to insulin stimulus
positive regulation of transcription from RNA polymerase II promoter
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