Invitrogen

LRP1 Polyclonal Antibody

LRP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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LRP1 Antibody (PA5-101013) in IHC (P)

Immunohistochemistry analysis of LRP1 in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with LRP1 polyclonal antibody (Product # PA5-101013) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.

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产品信息

PA5-101013

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:3,000

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免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:200

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human LRP1(Accession Q07954), corresponding to amino acid residues L4494-A4544.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2850489

产品详细信息

Antibody detects endogenous levels of total LRP1/CD91.

靶标信息

CD91 is a 600 kDa type I transmembrane protein composed of an alpha and beta chain. The alpha chain interacts with a variety of structurally and functionally diverse ligands, while the beta chain contains two tyrosine phosphorylation motifs that interact with adaptor and signaling proteins. This receptor is expressed by cells in the monocytic lineage, dendritic cells, hepatocytes, fibroblasts, adipocytes, neurons, and syncytiotrophoblasts. CD91 plays a crucial role in several cellular processes, including ligand endocytosis and trafficking to lysosomes, intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. It is involved in cross-presenting antigens via MHC class I molecules on antigen-presenting cells after endocytosis of heat shock protein-peptide complexes. Additionally, CD91 is essential for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of CD91 decreases with age and is found to be lower in brain tissue from Alzheimer patients compared to controls. The receptor also plays a role in cell migration and activating signaling cascades, highlighting its importance in both immune function and disease processes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice.

Nature communications

Wan T,Zhu W,Zhao Y,Zhang X,Ye R,Zuo M,Xu P,Huang Z,Zhang C,Xie Y,Liu X

Published figure using LRP1 polyclonal antibody (Product # PA5-101013) in Western Blot

Thu Mar 03 00:00:00 UTC 2022

Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice.

Nature communications

Wan T,Zhu W,Zhao Y,Zhang X,Ye R,Zuo M,Xu P,Huang Z,Zhang C,Xie Y,Liu X

Published figure using LRP1 polyclonal antibody (Product # PA5-101013) in Western Blot

Thu Mar 03 00:00:00 UTC 2022

生物信息学

蛋白别名: A2MR; alpha 2-macroglobulin receptor; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; CD91; FLJ16451; lipoprotein receptor-related protein; low density lipoprotein receptor-related protein 1; low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor); LRP-1; lrp1; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; type V tgf-beta receptor

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基因别名: A2MR; AI316852; APOER; APR; b2b1554Clo; CD91; IGFBP3R; LRP; LRP1; LRP1A; TGFBR5

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UniProt ID: (Human) Q07954, (Mouse) Q91ZX7, (Rat) G3V928

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Entrez Gene ID: (Human) 4035, (Mouse) 16971, (Rat) 299858

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功能