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Sequence homology: Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
LRRC33 is a key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. It associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. It is able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta and controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Leucine-rich repeat-containing protein 33; Negative regulator of reactive oxygen species; Transforming growth factor beta activator LRRC33
基因别名: ELLP3030; GARPL1; LRRC33; NRROS; UNQ3030; UNQ3030/PRO9833
UniProt ID: (Human) Q86YC3
Entrez Gene ID: (Human) 375387
