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Invitrogen

LSD1 Recombinant Rabbit Monoclonal Antibody (9P7B7)

查看其他29个LSD1抗体

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产品信息

MA569236

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:200-1:2,000
-

免疫细胞化学 (ICC/IF)

1:200-1:800
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Monkey, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

9P7B7

抗原

Recombinant protein (or fragment).

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.77 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3., with 50% glycerol

内含物

0.09% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: [histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A; amine oxidase (flavin containing) domain 2; BRAF35-HDAC complex protein BHC110; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; Flavin-containing amine oxidase domain-containing protein 2; Flavin-containingso amine oxidase domain-containing protein 2; lysine (K)-specific demethylase 1; lysine (K)-specific demethylase 1A; lysine-specific histone demethylase 1; Lysine-specific histone demethylase 1A; neuroprotective protein 3; RP1-184J9.1; unnamed protein product

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基因别名: 1810043O07Rik; AA408884; AIMAH3; AOF2; BHC110; CPRF; D4Ertd478e; KDM1; KDM1A; KIAA0601; LSD1; mKIAA0601; RGD1562975

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UniProt ID: (Human) Q96AW4, (Mouse) Q6ZQ88, (Rat) A0A8I6G2K8

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Entrez Gene ID: (Human) 23028, (Mouse) 99982, (Rat) 500569

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功能
p53 binding chromatin binding transcription coactivator activity transcription corepressor activity RNA binding protein binding oxidoreductase activity enzyme binding histone demethylase activity histone demethylase activity (H3-K4 specific) histone demethylase activity (H3-K9 specific) telomeric DNA binding identical protein binding MRF binding flavin adenine dinucleotide binding androgen receptor binding RNA polymerase II sequence-specific DNA binding transcription factor binding telomeric repeat-containing RNA binding DNA-binding transcription factor binding protein demethylase activity FAD-dependent H3K4me/H3K4me3 demethylase activity promoter-specific chromatin binding RNA polymerase II transcription factor binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor binding N-ethylmaleimide reductase activity ligand-dependent nuclear receptor transcription coactivator activity demethylase activity histone demethylase activity (H3-dimethyl-K4 specific) reduced coenzyme F420 dehydrogenase activity sulfur oxygenase reductase activity malolactic enzyme activity NADPH:sulfur oxidoreductase activity transcription regulatory region DNA binding epoxyqueuosine reductase activity oxidase
参与通路
negative regulation of transcription from RNA polymerase II promoter epithelial to mesenchymal transition positive regulation of neuroblast proliferation chromatin organization regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter regulation of double-strand break repair via homologous recombination positive regulation of epithelial to mesenchymal transition positive regulation of neuron projection development cerebral cortex development positive regulation of protein ubiquitination regulation of protein localization cellular response to UV protein modification process regulation of gene expression, epigenetic neuron maturation negative regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of cell differentiation positive regulation of cell size positive regulation of transcription from RNA polymerase II promoter guanine metabolic process regulation of neurogenesis positive regulation of multicellular organismal process muscle cell development regulation of androgen receptor signaling pathway response to fungicide cellular response to cAMP cellular response to gamma radiation positive regulation of cold-induced thermogenesis DNA repair-dependent chromatin remodeling negative regulation of transcription initiation-coupled chromatin remodeling negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation in utero embryonic development transcription, DNA-templated protein demethylation multicellular organism development cell proliferation regulation of primitive erythrocyte differentiation chromatin modification pituitary gland development granulocyte differentiation negative regulation of protein binding histone H3-K9 demethylation histone H3-K4 demethylation positive regulation of chromatin binding negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of erythrocyte differentiation positive regulation of megakaryocyte differentiation negative regulation of transcription, DNA-templated positive regulation of hormone biosynthetic process positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of histone H3-K4 methylation negative regulation of histone H3-K9 methylation oxidation-reduction process negative regulation of transcription from RNA polymerase II promoter by histone modification alternative mRNA splicing, via spliceosome response to organic cyclic compound
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