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Proteintech
LYAR Polyclonal Antibody
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产品信息
24433-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
LYAR Fusion Protein Ag19599 (6-357 aa encoded by BC015796)
偶联物
形式
Liquid
浓度
0.46 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: CNACGESVK KIQVEKHVSV CRNCECLSCI DCGKDFWGDD YKNHVKCISE DQKYGGKGYE GKTHKGDIKQ QAWIQKISEL IKRPNVSPKV RELLEQISAF DNVPRKKAKF QNWMKNSLKV HNESILDQVW NIFSEASNSE PVNKEQDQRP LHPVANPHAE ISTKVPASKV KDAVEQQGEV KKNKRERKEE RQKKRKREKK ELKLENHQEN SRNQKPKKRK KGQEADLEAG GEEVPEANGS AGKRSKKKKQ RKDSASEEEA RVGAGKRKRR HSEVETDSKK KKMKLPEHPE GGEPEDDEAP AKGKFNWKGT IKAILKQAPD NEITIKKLRK KVLAQYYTVT DEHHRSEEEL LVI (6-357 aa encoded by BC015796)
靶标信息
Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131). In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines (PubMed:31413131). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells. Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cell growth-regulating nucleolar protein; Ly1 antibody reactive homolog; Ly1 antibody-reactive protein; MLZ-264; Protein expressed in male leptotene and zygotene spermatocytes 264
基因别名: LYAR; MLZ-264; PNAS-5; ZC2HC2; ZLYAR
UniProt ID: (Human) Q9NX58, (Mouse) Q08288
Entrez Gene ID: (Human) 55646, (Mouse) 17089
