Search Thermo Fisher Scientific
This target displays homology in the following species: Cow: 79%; Dog: 100%; Guinea Pig: 85%; Horse: 86%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 91%; Rat: 85%
Immunoglobulin classes share the same basic four polypeptide chain structure of two heavy chains (five types) and two light chains (kappa, lambda; both having a molecular weight of 22.5 kDa). Kappa and lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of kappa to lambda is 70:30. Antibodies to the kappa light chain are reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Bence Jones Protein; BJP; IGL; IGLC 1/2/3; Immunoglobulin L; immunoglobulin lambda light chain; Lambda LC; Mcg Marker; Paraprotein
基因别名: IGLC; IGLV
Entrez Gene ID: (Human) 3537, (Human) 3546
分子生物学功能: immunoglobulin