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产品信息
MA5-18063
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:32,000 | - |
免疫细胞化学 (ICC/IF) |
Assay-dependent | - |
免疫沉淀 (IP) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Mouse / IgG1 |
分类 |
Monoclonal |
类型 |
Antibody |
克隆号 |
5H8-B4 |
抗原 |
Human Lamin A Ig-fold |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Protein G |
保存液 |
PBS |
内含物 |
0.1% sodium azide |
保存条件 |
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C |
RRID |
AB_2539446 |
产品详细信息
This antibody recognizes the FPLD-associated lamin A/C mutant strain R482W.
靶标信息
Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 70 kDa lamin; Lamin A+C mutant; lamin a-c; lamin A/C-like 1; Lamin AC; Lamin-A/C; mutant 453W; Mutant lamin A/C; Prelamin-A/C; progerin mutant; Renal carcinoma antigen NY-REN-32; RP11-54H19.1
基因别名: CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; PRO1
UniProt ID: (Human) P02545
Entrez Gene ID: (Human) 4000
mitotic nuclear envelope disassembly
mitotic nuclear envelope reassembly
spermatogenesis
response to mechanical stimulus
regulation of cell migration
establishment or maintenance of microtubule cytoskeleton polarity
protein localization to nucleus
sterol regulatory element binding protein import into nucleus
IRE1-mediated unfolded protein response
positive regulation of osteoblast differentiation
ventricular cardiac muscle cell development
cellular response to hypoxia
negative regulation of release of cytochrome c from mitochondria
positive regulation of cell aging
regulation of protein localization to nucleus
negative regulation of adipose tissue development
negative regulation of extrinsic apoptotic signaling pathway
