Invitrogen

Lamin B1 Recombinant Rabbit Monoclonal Antibody (SI17-07)

Lamin B1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Lamin B1 Antibody (MA5-32066) in IHC (P)

Immunohistochemical analysis of Lamin B1 was performed using formalin-fixed paraffin-embedded normal human skin tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - Low pH (10X) (Product # 00-4955-58) diluted to 1X solution in water in a decloaking chamber at 110 degree Celsius for 15 minut... View More

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产品信息

MA5-32066

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:5,000

免疫组化（石蜡） (IHC (P))

1:500-1:1000

免疫细胞化学 (ICC/IF)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

SI17-07

抗原

Synthetic peptide within Human Lamin B1 aa 511-560

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2809360

产品详细信息

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Defects in the LMNB1 gene can cause Leukodystrophy, demyelinating, autosomal dominant, adult-onset (ADLD).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease.

Cell stem cell

Herdy JR,Traxler L,Agarwal RK,Karbacher L,Schlachetzki JCM,Boehnke L,Zangwill D,Galasko D,Glass CK,Mertens J,Gage FH

MA5-32066 was used in Immunocytochemistry-immunofluorescence to show that targeting senescence-like neurons with senotherapeutics could be a strategy for preventing or treating AD.