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Antibody detects endogenous levels of total Mael.
The mammalian homolog of the Drosophila protein Maelstrom is expressed in the male germline and localizes to the sex body in spermatocytes and the chromatid body in round spermatids. Similar to its expression in Drosophila, Maelstrom is a component of nuages, a germ-cell specific organelle and is thought to be essential for spermatogenesis and transposon repression during meiosis. In humans, Maelstrom has been found to be expressed only in the testis and in various cancer cell lines. Treatment of these cell lines with the demethylating agent 5'-Aza-2-Deoxycytidine significantly upregulated Maelstrom levels, indicating that its expression is regulated by DNA methylation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cancer/testis antigen 128; maelstrom homolog; Protein maelstrom homolog; RP11-102C16.1; spermatogenesis associated 35; testicular tissue protein Li 116
基因别名: CT128; MAEL; SPATA35
UniProt ID: (Human) Q96JY0
Entrez Gene ID: (Human) 84944