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Proteintech
MAGI2 Polyclonal Antibody
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产品信息
25189-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: DRPPHSLHSM PTDGQLDGTY PPPVHDDNVS MASSGATQAE LMTLTIVKGA QGFGFTIADS PTGQRVKQIL DIQGCPGLCE GDLIVEINQQ NVQNLSHTEV VDILKDCPIG SETSLIIHRG GFFSPWKTPK PIMDRWENQG SPQTSLSAPA IPQNLPFPPA LHRSSFPDST EAFDPRKPDP YELYEKSRAI YESRRPDYKE LDVHLRRMES GFGFRILGGD EPGQPILIGA VIAMGSADRD GRLHPGDELV YVDGIPVAGK THRYVIDLMH HAARNGQVNL TVRRKVLCGG EPCPENGRSP GSVSTHHSSP RSDYATYTNS NHAAPSSNAS PPEGFASHSL QTSDVVIHRK
靶标信息
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. Florindo C.S., Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. The MGC Project Team, Genome Res. 14:2121-2127(2004). Devroe E., J. Biol. Chem. 279:24444-24451(2004).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activin receptor interacting protein 1; Activin receptor-interacting protein 1; Acvrip1; AIP-1; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; MAGI-2; Membrane-associated guanylate kinase inverted 2; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; S-SCAM; Synaptic-scaffolding molecule
基因别名: Acvri1; ACVRINP1; ACVRIP1; AIP-1; AIP1; ARIP1; KIAA0705; MAGI-2; MAGI2; mKIAA0705; S-SCAM; SSCAM
UniProt ID: (Human) Q86UL8, (Rat) O88382, (Mouse) Q9WVQ1
Entrez Gene ID: (Human) 9863, (Rat) 113970, (Mouse) 50791
positive regulation of receptor internalization
glomerular filtration
signal transduction
negative regulation of cell proliferation
positive regulation of neuron projection development
phosphorylation
cytosolic transport
negative regulation of cell migration
positive regulation of phosphoprotein phosphatase activity
negative regulation of activin receptor signaling pathway
nerve growth factor signaling pathway
receptor clustering
protein heterooligomerization
negative regulation of protein kinase B signaling
SMAD protein signal transduction
mitotic cell cycle arrest
glomerular visceral epithelial cell development
cellular response to nerve growth factor stimulus
planar cell polarity pathway involved in axis elongation
neuroligin clustering involved in postsynaptic membrane assembly
positive regulation of synaptic vesicle clustering
nervous system development
