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Proteintech
MAGI2 Recombinant Rabbit Monoclonal Antibody (240512C10)
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产品信息
83561-6-RR
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
240512C10
抗原
MAGI2 fusion protein Ag18279
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence:
DRPPHSLHS MPTDGQLDGT YPPPVHDDNV SMASSGATQA ELMTLTIVKG AQGFGFTIAD SPTGQRVKQI LDIQGCPGLC EGDLIVEINQ QNVQNLSHTE VVDILKDCPI GSETSLIIHR GGFFSPWKTP KPIMDRWENQ GSPQTSLSAP AIPQNLPFPP ALHRSSFPDS TEAFDPRKPD PYELYEKSRA IYESRRPDYK ELDVHLRRME SGFGFRILGG DEPGQPILIG AVIAMGSADR DGRLHPGDEL VYVDGIPVAG KTHRYVIDLM HHAARNGQVN LTVRRKVLCG GEPCPENGRS PGSVSTHHSS PRSDYATYTN SNHAAPSSNA SPPEGFASHS LQTSDVVIHR K
靶标信息
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. Florindo C.S., Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. The MGC Project Team, Genome Res. 14:2121-2127(2004). Devroe E., J. Biol. Chem. 279:24444-24451(2004).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activin receptor interacting protein 1; AIP-1; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; MAGI-2; MAGUK-like protein with 5 PDZ domains, 2 WW domains and a guanylate kinase-like domain; Membrane-associated guanylate kinase inverted 2; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; S-SCAM; Synaptic-scaffolding molecule; unnamed protein product
基因别名: ACVRINP1; ACVRIP1; AIP-1; AIP1; ARIP1; KIAA0705; MAGI-2; MAGI2; NPHS15; S-SCAM; SSCAM
UniProt ID: (Human) Q86UL8, (Rat) O88382
Entrez Gene ID: (Human) 9863, (Rat) 113970
positive regulation of receptor internalization
endocytosis
signal transduction
nervous system development
negative regulation of cell proliferation
positive regulation of neuron projection development
negative regulation of cell migration
negative regulation of activin receptor signaling pathway
nerve growth factor signaling pathway
receptor clustering
negative regulation of protein kinase B signaling
Wnt signaling pathway, planar cell polarity pathway
SMAD protein signal transduction
glomerular visceral epithelial cell development
clathrin-mediated endocytosis
cellular response to nerve growth factor stimulus
glomerular filtration
phosphorylation
cytosolic transport
positive regulation of phosphoprotein phosphatase activity
protein heterooligomerization
mitotic cell cycle arrest
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