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产品信息
PA5-64925
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫细胞化学 (ICC/IF) |
0.25-2 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant Human MAGI3 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.05 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.2, with 40% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2663569 |
产品详细信息
Immunogen sequence: LKVGDHISAVN GQSIVELSHD NIVQLIKDAG VTVTLTVIAE EEHHGPPSGT NSARQSPALQ HRPMGQSQAN HIPGDRSALE GEIGKDVSTS YRHSWSDHKH LAQPDTAVIS VVGSRHNQNL GCYPVELERG PRGFGFSLRG
Highest antigen sequence identity to the following orthologs - mouse 94%, rat 93%.
靶标信息
Membrane-associated guanylate kinase with inverted orientation (MAGI3) is a novel, 130 kDa guanylate kinase which is part of a family of multi-PDZ domain containing guanylate kinases. These guanylate kinases are localized to epithelial cell tight junctions. MAGI3 and PTEN/MMAC cooperate to modulate the kinase activity of AKT/protein kinase B (PKB). MAGI3 positions the PTEN/MMAC phosphatase to specific subcellular locations that are involved with the regulation of cell proliferation and survival. MAGI3, as well as other proteins in this family, are made up of an N-terminal guanylate kinase domain, followed by a WW domain, named for two conserved tryptophan residues and first identified as two repeats in mouse YAP65, which is them followed by 5 PDZ domains.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GKWW domain; MAGI-3; Membrane-associated guanylate kinase inverted 3; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; membrane-associated guanylate kinase-related 3; PDZ 4-5; RP4-730K3.1
基因别名: dJ730K3.2; KIAA1634; MAGI-3; MAGI3
UniProt ID: (Human) Q5TCQ9
Entrez Gene ID: (Human) 260425
