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Recommended positive controls: A431, HeLa, HepG2.
Predicted reactivity: Mouse (81%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: alpha 1,2-endomannosidase; Endo-alpha mannosidase; endomannosidase; Glycoprotein endo-alpha-1,2-mannosidase; Mandaselin; mannosidase, endo-alpha; mEndo
基因别名: 4932703L02Rik; ENDO; hEndo; MANEA
UniProt ID: (Human) Q5SRI9, (Mouse) Q6NXH2
Entrez Gene ID: (Human) 79694, (Mouse) 242362