Invitrogen

MAP4K3 Polyclonal Antibody

产品信息

PA5-50275

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:500-1:2,000	-
免疫组化（石蜡） (IHC (P))	1:25-1:100	-

产品规格
种属反应	Human, Mouse
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Fusion protein corresponding to a region derived from internal residues of human Mitogen-activated protein kinase kinase kinase kinase 3
偶联物	Unconjugated
形式	Liquid
浓度	1.3 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.4, with 40% glycerol
内含物	0.05% sodium azide
保存条件	-20°C
RRID	AB_2635728

产品详细信息

The antibody detects endogenous levels of total MAP4K3 protein.

靶标信息

MAP4K3 encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase 3 (MAP4K3).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: germinal center kinase-like kinase; Germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; mitogen activated protein kinase kinase kinase kinase 3; Mitogen-activated protein kinase kinase kinase kinase 3

基因别名: 4833416M01Rik; 4833416M07Rik; 9530052P13Rik; GLK; MAP4K3; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1

UniProt ID: (Human) Q8IVH8, (Mouse) Q99JP0

Entrez Gene ID: (Human) 8491, (Mouse) 225028

分子生物学功能: voltage-gated ion channel