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MAPK10 Monoclonal Antibody (3A3-1A8)
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产品信息
H00005602-M03
产品规格
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
3A3-1A8
抗原
MAPK10 (AAH65516.1, 1 a.a. approximately 319 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
See Label
规格
100 µg
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MELMDANLCQ VIQMELDHER MSYLLYQMLC GIKHLHSAGI IHRDLKPSNI VVKSDCTLKI LDFGLARTAG TSFMMTPYVV TRYYRAPEVI LGMGYKENVD IWSVGCIMGE MVRHKILFPG RDYIDQWNKV IEQLGTPCPE FMKKLQPTVR NYVENRPKYA GLTFPKLFPD SLFPADSEHN KLKASQARDL LSKMLVIDPA KRISVDDALQ HPYINVWYDP AEVEAPPPQI YDKQLDEREH TIEEWKELIY KEVMNSEEKT KNGVVKGQPS PSGAAVNSSE SLPPSSSVND ISSMSTDQTL ASDTDSSLEA SAGPLGCCR
靶标信息
MAPK10 (JNK3) is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). MAPK10 is involved in neuronal apoptosis and phosphorylates MAP2K4. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (NhpK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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