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Abnova
MAPKBP1 Polyclonal Antibody, MaxPab™
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产品信息
H00023005-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MAPKBP1 (AAH36660.1, 1 a.a. approximately 1015 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MGTLRVHELQ SLSEMLKVEA HDSEILCLEY SKPDTGLKLL ASASRDRLIH VLDAGREYSL QQTLDEHSSS ITAVKFAASD GQVRMISCGA DKSIYFRTAQ KSGDGVQFTR THHVVRKTTL YDMDVEPSWK YTAIGCQDRN IRIFNISSGK QKKLFKGSQG EDGTLIKVQT DPSGIYIATS CSDKNLSIFD FSSGECVATM FGHSEIVTGM KFSNDCKHLI SVSGDSCIFV WRLSSEMTIS MRQRLAELRQ RQRGGKQQGP SSPQRASGPN RHQAPSMLSP GPALSSDSDK EGEDEGTEEE LPALPVLAKS TKKALASVPS PALPRSLSHW EMSRAQESVG FLDSAPAANP GPRRRGRWVQ PGVELSVRSM LDLRQLETLA PSLQDPSQDS LAIIPSGPRK HGQEALETSL TSQNEKPPRP QASQPCSYPH IIRLLSQEEG VFAQDLEPAP IEDGIVYPEP SDNPTMDTSE FQVQAPARGT LGRVYPGSRS SEKHSPDSAC SVDYSSSCLS SPEHPTEDSE STEPLSVDGI SSDLEEPAEG DEEEEEEEGG MGPYGLQEGS PQTPDQEQFL KQHFETLASG AAPGAPVQVP ERSESRSISS RFLLQVQTRP LREPSPSSSS LALMSRPAQV PQASGEQPRG NGANPPGAPP EVEPSSGNPS PQQAASVLLP RCRLNPDSSW APKRVATASP FSGLQKAQSV HSLVPQERHE ASLQAPSPGA LLSREIEAQD GLGSLPPADG PPSRPHSYQN PTTSSMAKIS RSISVGENLG LVAEPQAHAP IRVSPLSKLA LPSRAHLVLD IPKPLPDRPT LAAFSPVTKG RAPGEAEKPG FPVGLGKAHS TTERWACLGE GTTPKPRTEC QAHPGPSSPC AQQLPVSSLF QGPENLQPPP PEKTPNPMEC TKPGAALSQD SEPAVSLEQC EQLVAELRGS VRQAVRLYHS VAGCKMPSAE QSRIAQLLRD TFSSVRQELE AVAGAVLSSP GSSPGAVGAE QTQALLEQYS ELLLRAVERR MERKL
靶标信息
MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. MAPKBP-1 (mitogen-activated protein kinase binding protein 1), also known as JNKBP-1, is a 1,514 amino acid protein that contains twelve WD repeats. Induced by TRAF2 (TNF receptor-associated factor 2) and Tak1 (TGF-beta-activated kinase 1), MAPKBP-1 is thought to act an adaptor protein for NFkappaB (nuclear factor kappa-B) activation. MAPKBP-1 interacts with JNK3 and may promote TRAF2 polyubiquitination. MAPKBP-1 exists as six alternatively spliced variants and is encoded by a gene located on human chromosome 15. Human chromosome 15 houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: JNK-binding protein 1; JNKBP-1; mitogen activated protein kinase binding protein 1; Mitogen-activated protein kinase-binding protein 1
基因别名: JNKBP-1; JNKBP1; KIAA0596; MAPKBP1
UniProt ID: (Human) O60336
Entrez Gene ID: (Human) 23005
