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Immunogen sequence: MLPPPPRQPP PQARAARGAV RLQRPFLRSP LGVLRLLQLL AGAAFWITIA
MARVELD1, (MARVEL domain-containing 1), is one of the MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain-containing proteins. It is a nuclear-localized protein that is widely expressed in normal human tissues. While it has been reported to be overexpressed in colon cancer, MARVELD1 protein levels are generally lower in several primary tumors including ovary, breast, kidney, bladder and liver. This lower level of MARVELD1 expression in tumors is thought to be due to a higher methylation status of the MARVELD1 promoter as treatment of MDA-MB-361 with 5-aza-2'-deoxycytidine restores MARVELD1 expression, suggesting that loss of MARVELD1 expression may contribute to tumorgenicity.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: MARVEL (membrane-associating) domain containing 1; MARVEL domain-containing protein 1; putative MARVEL domain-containing protein 1; RP11-548K23.8
基因别名: AI504298; bA548K23.8; GB14; MARVD1; MARVELD1; MRVLDC1
UniProt ID: (Human) Q9BSK0, (Mouse) Q7TQJ1
Entrez Gene ID: (Human) 83742, (Rat) 309375, (Mouse) 277010
分子生物学功能: membrane traffic protein