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Positive Samples: HeLa
Immunogen sequence: HTVELNNMFG QIQSPGYPDS YPSDSEVTWN ITVPDGFRIK LYFMHFNLES SYLCEYDYVK VETEDQVLAT FCGRETTDTE QTPGQEVVLS PGSFMSITFR SDFSNEERFT GFDAHYMAVD VDECKEREDE ELSCDHYCHN YIGGYYCSCR FGYILHTDNR TCRVECSDNL FTQRTGVITS PDFPNPYPKS SECLYTIELE EGFMVNLQFE DIFDIEDHPE VPCPYDYIKI KVGPKVLGPF CGEKAPEPIS TQSHSVLILF HSDNSGENRG WRLSYRAAGN E
MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, three types of MBL-associated serine proteases, MASP-1, MASP-2 and MASP-3, and a truncated form of MASP-2 (small MBL-associated protein; sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system. MASP-3 is an alternatively spliced product from the MASP-1 gene. The heavy/A chains are identical between MASP-1 and MASP-3 but the light/B chains are entirely different. Activated MASPs subsequently cleave and activate downstream components of the complement pathway.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: C4/C2 activating component of Ra-reactive factor; Complement factor MASP-3; Complement-activating component of Ra-reactive factor; mannan-binding; mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor); Mannan-binding lectin serine protease 1; Mannose-binding lectin-associated serine protease 1; mannose-binding protein associated serine protease-1; Mannose-binding protein-associated serine protease; MASP-1; Ra-reactive factor serine protease p100; RaRF; Serine protease 5; serine protease MASP1
基因别名: 3MC1; AW048060; CCPII; CRARF; CRARF1; MAP1; MAp44; MASP; MASP1; Masp1/3; MASP3; PRSS5; RaRF
UniProt ID: (Human) Q9UF09, (Mouse) P98064, (Rat) Q8CHN8
Entrez Gene ID: (Human) 5648, (Mouse) 17174, (Rat) 64023
分子生物学功能:
serine protease