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Invitrogen
MAVS Recombinant Rabbit Monoclonal Antibody (PSH0-30)
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MAVS Antibody (MA5-50801) in ICC/IF
Immunocytochemistry analysis of MAVS in A431 cells. Cells were fixed in 4% paraformaldehyde for 10 minutes at 37 &(8)451;, permeabilized with 0.05% Triton X-100 in PBS for 20 minutes, and then blocked with 2% negative goat serum for 30 minutes at room temperature. Cells were incubated with MAVS recombinant monoclonal antibody (Product # MA5-50801) with a dilution of 1:100 in 2% negative goat serum overnight at 4 &(8)451;. Followed by secondary antibody Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) at a dilution of 1:1,000. Nuclear DNA was la... View More
产品信息
MA5-50801
产品规格
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH0-30
抗原
Synthetic peptide within human MAVS aa 2-50/540.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Positive control: MCF7 cell lysate, C2C12 cell lysate, human colon tissue, human endometrium tissue, A431 cell.
Predicted band size: 56 kDa
Subcellular Location: Membrane, Mitochondrion, Mitochondrion outer membrane, Peroxisome.
靶标信息
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. MAVS is a mitochondrial membrane protein that was identified as a critical component in the IFN beta signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. MAVS is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. MAVS also interacts with the IKK-alpha, IKK-beta and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. Multiple isoforms of MAVS are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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