Clone 314G8 recognizes human MAdCAM-1 under non-reducing conditions. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL. In Western blot, this antibody detects a band at ~60 kDa.
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.
蛋白别名: hMAdCAM-1; MAdCAM-1; Mucosal addressin cell adhesion molecule 1; mucosal addressin cell adhesion molecule-1
基因别名: MACAM1; MADCAM1
UniProt ID: (Human) Q13477
Entrez Gene ID: (Human) 8174