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Synthetic peptide sequence: 290-317aa, NAIIDPLIYAFHSQELRRTLKEVLTCSW.
Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: alpha melanocyte stimulating hormone receptor; extension recessive yellow; MC1 receptor; MC1-R; melanocortin 1 receptor; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); Melanocortin receptor 1; melanocortin-1 receptor; Melanocyte-stimulating hormone receptor; melanotropin receptor; MSH-R; tobacco darkening
基因别名: CMM5; e; MC1R; MSH-R; MSHR; Mshra; SHEP2; Tob
UniProt ID: (Human) Q01726, (Mouse) Q01727
Entrez Gene ID: (Human) 4157, (Rat) 102552838, (Mouse) 17199
分子生物学功能:
G-protein coupled receptor
