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MCHR1 Antibody (702618) in ICC/IF
For immunofluorescence analysis, HEK-293 cells were stably transfected with human MCHR1. After 24hr of transfection the cells were fixed and permeabilized for detection of MCHR1 using Anti-MCHR1 Recombinant Rabbit Monoclonal Antibody (Product # 702618, 1 µg/mL, 1:500 dilution) and labeled with Goat anti-Rabbit IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate. Panel a) shows representative cells that were stained for detection of membrane localization of the MCHR1 on the transfected cells. The images were captured at 40... View More
产品信息
702618
产品规格
种属反应
Human,
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
12H4L9
抗原
Peptide corresponding to human MCHR1 [aa401-aa422]
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2734816
产品详细信息
This antibody is predicted to react with Monkey, Mouse, Rabbit.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
MCHR1 is a member of the G protein-coupled receptor family 1. It is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: G protein-coupled receptor 24; G-protein coupled receptor 24; GPCR24; MCH 1 receptor; MCH receptor 1; MCH-1R; MCH-R1; MCH1; MCH1R; MCHR; MCHR-1; Melanin-concentrating hormone receptor 1; SLC-1; Somatostatin receptor-like protein
基因别名: GPR24; MCH-1R; MCH1R; MCHR1; SLC-1; SLC1
UniProt ID: (Human) Q99705, (Rat) P97639
Entrez Gene ID: (Human) 2847, (Rat) 83567
generation of precursor metabolites and energy
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
feeding behavior
positive regulation of calcium ion transport
