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Invitrogen
MECP2 Polyclonal Antibody
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产品信息
PA1-30643
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mixture of synthetic peptides EKSEDQDLQGLKDKP and APGTGRGRGRPKGSG, corresponding to aminoacids 11-25 and 181-195, respectively (Human).
偶联物
形式
Liquid
浓度
0.5 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
PA1-30643 detects MeCP2 from human samples.
PA1-30643 has been successfully used in Western blot applications.
The PA1-30643 immunogen is a mixture of synthetic peptides EKSEDQDLQGLKDKP and APGTGRGRGRPKGSG, corresponding to aminoacids 11-25 and 181-195, respectively (Human).
靶标信息
MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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