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产品信息
PA5-50718
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化（石蜡） (IHC (P)) |
1:50-1:200 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide corresponding to a region derived from internal residues of human mediator complex subunit 12 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1.7 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 40% glycerol |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2636170 |
产品详细信息
The antibody detects endogenous levels of total MED12 / TRAP230 protein.
靶标信息
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; human opposite paired; Mediator complex subunit 12; Mediator of RNA polymerase II transcription subunit 12; mediator of RNA polymerase II transcription, subunit 12 homolog; OPA-containing protein; OPA-containing protein 1; putative mediator subunit 12; Thyroid hormone receptor-associated protein complex 230 kDa component; thyroid hormone receptor-associated protein, 230 kDa subunit; Trap230; trinucleotide repeat containing 11 (THR-associated protein); trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit); Trinucleotide repeat-containing gene 11 protein
基因别名: 230kDa; ARC240; CAGH45; FGS1; HOPA; KIAA0192; MED12; MED12S; Mopa; OHDOX; OKS; OPA-1; OPA1; TNRC11; TRAP230
UniProt ID: (Human) Q93074, (Mouse) A2AGH7
Entrez Gene ID: (Human) 9968, (Mouse) 59024
分子生物学功能:
general transcription factor
neural tube closure
transcription initiation from RNA polymerase II promoter
endoderm development
heart development
oligodendrocyte development
Schwann cell development
protein ubiquitination
stem cell population maintenance
spinal cord development
negative regulation of Wnt signaling pathway
intracellular steroid hormone receptor signaling pathway
androgen receptor signaling pathway
post-anal tail morphogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic neurocranium morphogenesis
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
axis elongation involved in somitogenesis
embryonic brain development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription cofactor activity
RNA polymerase II transcription coactivator activity
chromatin binding
transcription cofactor activity
transcription coactivator activity
receptor activity
protein binding
beta-catenin binding
protein C-terminus binding
protein domain specific binding
ligand-dependent nuclear receptor transcription coactivator activity
vitamin D receptor binding
thyroid hormone receptor binding
ubiquitin protein ligase activity
transcriptional activator activity, RNA polymerase II transcription factor binding
transcription factor binding
