Proteintech

MEK2 Polyclonal Antibody

39 篇参考文献
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MEK2 Polyclonal Antibody

产品信息

11049-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
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免疫细胞化学 (ICC/IF)

1:10-1:100
-

免疫沉淀 (IP)

0.5-4.0 µg
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human, Mouse

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

MEK2 Fusion Protein Ag1481 (1-400 aa encoded by BC018645)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.27 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

11049-1-AP can recognize both MEK2 and MEK1.

Immunogen sequence: MLARRKPVL PALTINPTIA EGPSPTSEGA SEANLVDLQK KLEELELDEQ QKKRLEAFLT QKAKVGELKD DDFERISELG AGNGGVVTKV QHRPSGLIMA RKLIHLEIKP AIRNQIIREL QVLHECNSPY IVGFYGAFYS DGEISICMEH MDGGSLDQVL KEAKRIPEEI LGKVSIAVLR GLAYLREKHQ IMHRDVKPSN ILVNSRGEIK LCDFGVSGQL IDSMANSFVG TRSYMAPERL QGTHYSVQSD IWSMGLSLVE LAVGRYPIPP PDAKELEAIF GRPVVDGEEG EPHSISPRPR PPGRPVSGHG MDSRPAMAIF ELLDYIVNEP PPKLPNGVFT PDFQEFVNKC LIKNPAERAD LKMLTNHTFI KRSEVEEVDF AGWLCKTLRL NQPGTPTRTA V (1-400 aa encoded by BC018645)

靶标信息

MAP2K2 (MEK2) is a dual specificity serine/threonine kinase that is known to play a critical role in mitogen growth factor signal transduction. Mitogen activated protein kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; ERK kinase 2; FLJ26075; MAP kinase kinase 2; MAP kinase/Erk kinase; MAP2K1; MAPK; MAPK/ERK kinase 1; MAPK/ERK kinase 2; MAPKK 1; MAPKK 2; MEK 1; MEK 2; MEK-1; MEK-2; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK1; OTTHUMP00000165827; PRKMK1; protein kinase, mitogen activated, kinase 2, p45

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基因别名: AA589381; CFC4; MAP2K2; MAPKK2; MEK2; MK2; MKK2; PRKMK2

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UniProt ID: (Human) P36507, (Mouse) Q63932

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Entrez Gene ID: (Human) 5605, (Mouse) 26396

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功能
protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity protein binding ATP binding PDZ domain binding protein complex scaffold protein serine/threonine kinase activator activity metal ion binding scaffold protein binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
参与通路
MAPK cascade activation of MAPK activity heart development negative regulation of gene expression peptidyl-tyrosine phosphorylation thyroid gland development regulation of stress-activated MAPK cascade proteolysis in other organism peptidyl-serine autophosphorylation positive regulation of transcription, DNA-templated thymus development regulation of axon regeneration positive regulation of axonogenesis face development trachea formation epithelial cell proliferation involved in lung morphogenesis ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of protein serine/threonine kinase activity regulation of Golgi inheritance positive regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of cell motility regulation of early endosome to late endosome transport regulation of protein phosphorylation protein phosphorylation phosphorylation lung morphogenesis
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