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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
0.1 µg/mL | - |
免疫组化 (IHC) |
5-15 µg/mL | - |
免疫沉淀 (IP) |
25 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Goat / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Mouse myeloma cell line NS0-derived recombinant human Meprin beta Subunit/MEP1B Leu21-Ser593 |
偶联物 |
Unconjugated |
形式 |
Lyophilized |
浓度 |
0.2 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS with 5% trehalose |
内含物 |
No Preservative |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2607664 |
In direct ELISAs and Western blots, approximately 45% cross-reactivity with recombinant mouse MEP1B is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: EC 3.4.24.63; Endopeptidase-2; meprin A; Meprin A subunit beta; meprin A, beta; Meprin B; N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; PABA peptide hydrolase; PPH beta
基因别名: MEP1B
UniProt ID: (Human) Q16820
Entrez Gene ID: (Human) 4225
分子生物学功能:
metalloprotease
