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Invitrogen
MERS Coronavirus Spike Protein S1 Polyclonal Antibody
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MERS Coronavirus Spike Protein S1 Antibody (PA5-119581) in WB
Western blot analysis of MERS Coronavirus Spike Protein S1 in non-transfected (–) and transfected (+) 293T whole cell extracts (30 µg). Samples were incubated with MERS Coronavirus Spike Protein S1 polyclonal antibody (Product # PA5-119581) using a dilution of 1:5,000 followed by HRP-conjugated anti-rabbit IgG. Separated by 5% SDS-PAGE.
产品信息
PA5-119581
产品规格
种属反应
Virus
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of MERS-CoV Spike (S1) (MERS-CoV (strain United Kingdom/H123990006/2012)). The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1.73 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, we recommend adding 50% glycerol, then aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
靶标信息
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell: they are essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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