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Proteintech
MESDC2 Polyclonal Antibody
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产品信息
10958-1-AP
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MESDC2 Fusion Protein Ag1403 (1-234 aa encoded by BC009210)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAASRWARK AVVLLCASDL LLLLLLLPPP GSCAAEGSPG TPDESTPPPR KKKKDIRDYN DADMARLLEQ WEKDDDIEEG DLPEHKRPSA PVDFSKIDPS KPESILKMTK KGKTLMMFVT VSGSPTEKET EEITSLWQGS LFNANYDVQR FIVGSDRAIF MLRDGSYAWE IKDFLVGQDR CADVTLEGQV YPGKGGGSKE KNKTKQDKGK KKKEGDLKSR SSKEENRAGN KREDL (1-234 aa encoded by BC009210)
靶标信息
MESDC2 chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: LDLR chaperone MESD; LRP chaperone MESD; Mesoderm development candidate 2; Mesoderm development LRP chaperone MESD; Mesoderm development protein; Renal carcinoma antigen NY-REN-61
基因别名: 2210015O11Rik; AW537813; BOCA; KIAA0081; MESD; MESDC2; MESDM; mKIAA0081; msd; UNQ1911/PRO4369
UniProt ID: (Human) Q14696, (Mouse) Q9ERE7
Entrez Gene ID: (Human) 23184, (Mouse) 67943
