This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15.
蛋白别名: DKFZp686L18234; Mesoderm-specific transcript homolog protein; Mesoderm-specific transcript protein; MGC111102; MGC8703; Paternally-expressed gene 1 protein
基因别名: 121a; AA408879; AI256745; MEST; PEG1
分子生物学功能: serine protease