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MFN1 Antibody (PA5-97281) in WB
Western blot analysis of MFN1 in various lysates. Samples were incubated with MFN1 Polyclonal antibody (Product # PA5-97281) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-97281
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to amino acids 1-100 of human MFN1.
偶联物
Unconjugated
形式
Liquid
浓度
3.78 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2809083
产品详细信息
Immunogen sequence: MAEPVSPLKH FVLAKKAITA IFDQLLEFVT EGSHFVEATY KNPELDRIAT EDDLVEMQGY KDKLSIIGEV LSRRHMKVAF FGRTSSGKSS VINAMLWDKV
Positive Samples: A-549, LO2, SW480, Mouse liver, Mouse kidney; Cellular Location: Cytoplasm, Mitochondrion outer membrane, Multi-pass membrane protein
靶标信息
Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp762F247; EC 3.6.5; FLJ20693; Fzo homolog; MGC41806; mitochondrial transmembrane GTPase Fzo-1; mitochondrial transmembrane GTPase FZO-2; Mitochondrial transmembrane GTPase FZO1B; Mitofusin-1; putative transmembrane GTPase; Transmembrane GTPase MFN1
基因别名: 2310002F04Rik; 6330416C07Rik; D3Ertd265e; Fzo1b; hfzo1; hfzo2; HR2; MFN1; mKIAA4032
UniProt ID: (Human) Q8IWA4, (Rat) Q8R4Z9, (Mouse) Q9D395
Entrez Gene ID: (Human) 55669, (Rat) 192647, (Mouse) 67414
