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MFN2 Antibody (PA5-119645) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of of Mitofusin 2 in PC-3M cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 10% negative goat serum for 15 minutes at room temperature. Cells were probed with MFN2 Polyclonal Antibody (Product # PA5-119645) at a dilution of 1:50 for 1 hour at room temperature, washed with PBS. Alexa Fluor 488 conjugate-Goat anti-Rabbit IgG was used as the secondary antibody at 1:1,000 dilution. The nuclear counter stain is... View More
产品信息
PA5-119645
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein within human Mitofusin 2 aa 378-602
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2913218
产品详细信息
Positive Control: Rat heart tissue lysates, A431, LOVO, PC-3M, Jurkat.
Subcellular Location: Mitochondrion.
靶标信息
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CPRP 1; hyperplasia suppressor; hypertension-related protein; MFN 2; mitochondrial assembly regulatory factor; mitochondrial transmembrane GTPase FZO1A; Mitofusin-2; Mitofusin2; Transmembrane GTPase MFN2
基因别名: CMT2A; CMT2A2; CPRP1; HMSN6A; HSG; KIAA0214; MARF; MFN2
UniProt ID: (Human) O95140
Entrez Gene ID: (Human) 9927, (Rat) 64476
blastocyst formation
protein targeting to mitochondrion
apoptotic process
response to unfolded protein
mitochondrial membrane organization
cell cycle arrest
blood coagulation
mitochondrial fusion
macroautophagy
protein localization to pre-autophagosomal structure
negative regulation of Ras protein signal transduction
camera-type eye morphogenesis
negative regulation of smooth muscle cell proliferation
mitochondrion localization
parkin-mediated mitophagy in response to mitochondrial depolarization
autophagy
metabolic process
negative regulation of cell proliferation
