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MICALs (Molecules Interacting with CasL) are atypical multidomain flavoenzymes with diverse cellular functions. There are three known isoforms, MICAL1, MICAL2 and MICAL3, as well as the MICAL-like proteins MICAL-L1 and MICAL-L2. MICAL2 has three conserved domains: an N-terminal flavin adenine dinucleotide (FAD) binding domain, a calponin homology (CH) domain and a Lin11, Isl-1 and Mec-3 (LIM) domain. It has been demonstrated that MICAL2 could regulate actin stress fibers and is required for normal actin organization. In addition, MICAL2-PV, a novel splicing variants of MICAL2, has been reported to be involved in cancer progression of prostate cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: [F-actin]-monooxygenase MICAL2; ERK2-binding testicular protein 1; flavoprotein oxidoreductase MICAL2; MICAL C-terminal-like protein; MICAL-2; Mical-cL; microtubule associated monoxygenase, calponin and LIM domain containing 2; mMical2; Molecule interacting with CasL protein 2; protein MICAL-2; Protein RSB-11-77; protein-methionine sulfoxide oxidase MICAL2
基因别名: 5330438E18Rik; 9530064J02; KIAA0750; MICAL-2; MICAL2; MICAL2PV1; MICAL2PV2; MICALCL; mKIAA0750; RGD1311773
UniProt ID: (Human) Q5KTR4, (Rat) D4A1F2, (Mouse) Q8BML1
Entrez Gene ID: (Human) 9645, (Rat) 365352, (Mouse) 320878