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Invitrogen
MICAL3 Polyclonal Antibody
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产品信息
PA5-65130
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MELASGAPRPR KASSAPSQGK ERRPDSPTRP TLRGSEEPTL KHEATSEEVL SPPSDSGGPD GSFTSSEGSS GKSKKRSSLF SPRRNKKEKK
Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 75%.
靶标信息
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: [F-actin]-monooxygenase MICAL3; flavoprotein oxidoreductase MICAL3; MICAL-3; Molecule interacting with CasL protein 3; protein MICAL-3
基因别名: KIAA0819; KIAA1364; MICAL-3; MICAL3
UniProt ID: (Human) Q7RTP6
Entrez Gene ID: (Human) 57553
