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Abnova
MICAL3 Monoclonal Antibody (3A6)
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产品信息
H00057553-M08
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3A6
抗原
MICAL3 (XP_032996.2, 251 a.a. approximately 340 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: DDQHWSDSPS DADRELRLPC PAEGEAELEL RVSEDEEKLP ASPKHQERGP SQATSPIRSP QESALLFIPV HSPSTEGPQL PPVPAATQEK
靶标信息
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: [F-actin]-monooxygenase MICAL3; flavoprotein oxidoreductase MICAL3; MICAL-3; Molecule interacting with CasL protein 3; protein MICAL-3
基因别名: KIAA0819; KIAA1364; MICAL-3; MICAL3
UniProt ID: (Human) Q7RTP6
Entrez Gene ID: (Human) 57553
