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Proteintech
MINA Polyclonal Antibody
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产品信息
12214-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MINA Fusion Protein Ag2838 (160-465 aa encoded by BC014928)
偶联物
形式
Liquid
浓度
0.23 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: SLVGSNVYI TPAGSQGLPP HYDDVEVFIL QLEGEKHWRL YHPTVPLARE YSVEAEERIG RPVHEFMLKP GDLLYFPRGT IHQADTPAGL AHSTHVTIST YQNNSWGDFL LDTISGLVFD TAKEDVELRT GIPRQLLLQV ESTTVATRRL SGFLRTLADR LEGTKELLSS DMKKDFIMHR LPPYSAGDGA ELSTPGGKLP RLDSVVRLQF KDHIVLTVLP DQDQSDETQE KMVYIYHSLK NSRETHMMGN EEETEFHGLR FPLSHLDALK QIWNSPAISV KDLKLTTDEE KESLVLSLWT ECLIQVV (160-465 aa encoded by BC014928 )
靶标信息
MINA is nuclear localized, myc-inducible protein that is thought to play a role in mammalian cell proliferation. Treatment of cancer cells lines such as the colon cancer cell line SW680 with siRNA against MINA inhibits cell growth, demonstrating that MINA may be a potential therapeutic target. MINA regulates several genes related to cell adhesion and metabolism that have also been shown to be regulated by c-Myc, but also regulates other genes whose expression are not modulated by c-Myc such as EGFR, IL-6 and HGF. MINA has also been found to act as a repressor to IL-4 expression in T cells, indicating that it may also play a role in T cell differentiation and genetic variation in T helper type 2 bias.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 60S ribosomal protein L27a histidine hydroxylase; Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; DKFZp762O1912; FLJ14393; Histone lysine demethylase MINA; MINA; mina {ECO:0000312|RGD:708521}; Mina-53; mineral dust induced gene protein; Mineral dust-induced gene protein; MYC-induced nuclear antigen; myc-induced nuclear antigen, 53 kDa; Nucleolar protein 52; Protein mina53; Ribosomal oxygenase 2; Ribosomal oxygenase MINA; ROX
基因别名: 1810047J07Rik; 2410057H13Rik; 3830408E23Rik; AI449204; MDIG; MINA; MINA53; NO52; RIOX2; ROX
UniProt ID: (Human) Q8IUF8, (Mouse) Q8CD15, (Rat) Q8CFC1
Entrez Gene ID: (Human) 84864, (Mouse) 67014, (Rat) 266670
transcriptional repressor activity, RNA polymerase II transcription factor binding
iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
sulfonate dioxygenase activity
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
metal ion binding
dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
peptidyl-amino acid modification
ribosome biogenesis
post-translational protein modification
negative regulation of transcription, DNA-templated
oxidation-reduction process
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
cell proliferation
regulation of cell proliferation
