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MIP-1 alpha Polyclonal Antibody

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说明书
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说明书
实验方案
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说明书
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MIP-1 alpha Polyclonal Antibody

产品信息

109-401-315-0100

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

酶联免疫吸附实验 (ELISA)

1:1,000-1:5,000
-

免疫沉淀 (IP)

1:500-1:2,000
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

The whole rabbit serum was prepared by repeated immunizations with recombinant human MIP-1a produced in E.coli.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

85 mg/mL

保存液

whole serum

内含物

0.01% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

In ELISA formats and other immunoreactive assays, this antibody will recognize recombinant and native human MIP-1a present in body fluids and cell supernatants. This antiserum has not been evaluated for its ability to stain human MIP-1a in tissue sections, nor for its ability to neutralize human MIP-1a in bioassays, nor for its performance in immunoblot analysis.

靶标信息

Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1alpha and MIP-1beta exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes, and MIP-1beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: C-C motif chemokine 3; chemokine (C-C motif) ligand 3; G0/G1 switch regulatory protein 19-1; H-MIP-1-alpha; LD78-alpha; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; mip1 alpha; PAT 464.1; RP23-320E6.7; SIS-beta; small inducible cytokine A3 (homologous to mouse Mip-1a); Small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein

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基因别名: CCL3; G0S19-1; LD78ALPHA; MIP-1-alpha; MIP1A; SCYA3

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UniProt ID: (Human) P10147

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Entrez Gene ID: (Human) 6348

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功能
protein kinase activity calcium-dependent protein kinase C activity protein binding chemokine activity phospholipase activator activity kinase activity CCR1 chemokine receptor binding CCR5 chemokine receptor binding chemoattractant activity identical protein binding cytokine intercellular signal molecule
参与通路
MAPK cascade osteoblast differentiation cell activation monocyte chemotaxis calcium ion transport cellular calcium ion homeostasis exocytosis chemotaxis inflammatory response cytoskeleton organization G-protein coupled receptor signaling pathway cell-cell signaling behavior regulation of cell shape response to toxic substance positive regulation of gene expression negative regulation of gene expression T cell chemotaxis release of sequestered calcium ion into cytosol by sarcoplasmic reticulum calcium-mediated signaling signaling positive regulation of cell migration negative regulation of bone mineralization neutrophil chemotaxis lipopolysaccharide-mediated signaling pathway positive regulation of tumor necrosis factor production eosinophil degranulation protein kinase B signaling positive regulation of neuron apoptotic process positive regulation of GTPase activity astrocyte cell migration negative regulation by host of viral transcription negative regulation of osteoclast differentiation eosinophil chemotaxis macrophage chemotaxis lymphocyte chemotaxis positive regulation of interleukin-1 beta secretion positive regulation of inflammatory response positive regulation of calcium-mediated signaling positive chemotaxis positive regulation of protein kinase B signaling positive regulation of calcium ion transport regulation of sensory perception of pain chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade response to cholesterol cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to organic cyclic compound granulocyte chemotaxis positive regulation of calcium ion import positive regulation of natural killer cell chemotaxis
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