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Proteintech
MKP-2 Monoclonal Antibody (1G1C12)
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产品信息
66349-1-IG
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1G1C12
抗原
MKP-2 Fusion Protein Ag1206 (1-394 aa encoded by BC014565)
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MVTMEELRE MDCSVLKRLM NRDENGGGAG GSGSHGTLGL PSGGKCLLLD CRPFLAHSAG YILGSVNVRC NTIVRRRAKG SVSLEQILPA EEEVRARLRS GLYSAVIVYD ERSPRAESLR EDSTVSLVVQ ALRRNAERTD ICLLKGGYER FSSEYPEFCS KTKALAAIPP PVPPSATEPL DLGCSSCGTP LHDQGGPVEI LPFLYLGSAY HAARRDMLDA LGITALLNVS SDCPNHFEGH YQYKCIPVED NHKADISSWF MEAIEYIDAV KDCRGRVLVH CQAGISRSAT ICLAYLMMKK RVRLEEAFEF VKQRRSIISP NFSFMGQLLQ FESQVLATSC AAEAASPSGP LRERGKTPAT PTSQFVFSFP VSVGVHSAPS SLPYLHSPIT TSPSC (1-394 aa encoded by BC014565)
靶标信息
DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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