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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
MAP3K11 (MLK3) is a serine/threonine kinase that activates both the p38 MAP kinase and c-Jun kinase pathways. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: MGC17114; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase
基因别名: MAP3K11; MLK3; PTK1; SPRK
Entrez Gene ID: (Human) 4296