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Proteintech
MLN64 Polyclonal Antibody
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产品信息
20292-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MLN64 Fusion Protein Ag14061 (170-445 aa encoded by BC008747)
偶联物
形式
Liquid
浓度
0.15 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: DFKVLPQEA EEERWYLAAQ VAVARGPLLF SGALSEGQFY SPPESFAGSD NESDEEVAGK KSFSAQEREY IRQGKEATAV VDQILAQEEN WKFEKNNEYG DTVYTIEVPF HGKTFILKTF LPCPAELVYQ EVILQPERMV LWNKTVTACQ ILQRVEDNTL ISYDVSAGAA GGVVSPRDFV NVRRIERRRD RYLSSGIATS HSAKPPTHKY VRGENGPGGF IVLKSASNPR VCTFVWILNT DLKGRLPRYL IHQSLAATMF EFAFHLRQRI SELGARA (170-445 aa encoded by BC008747 )
靶标信息
The steroidogenic acute regulatory (StAR) protein facilitates the movement of cholesterol from the outer to inner mitochondrial membrane in adrenal and gonadal cells, fostering steroid biosynthesis. MLN64 is a 445-amino acid protein of unknown function. When 218 amino-terminal residues of MLN64 are deleted, the resulting N-218 MLN64 has 37% amino acid identity with StAR and 50% of StAR's steroidogenic activity in transfected cells. Bacterially expressed N-218 MLN64 exerts StAR-like activity to promote the transfer of cholesterol from the outer to inner mitochondrial membrane in vitro. The presence of a protease-resistant domain and a protease-sensitive carboxy-terminal domain in N-218 MLN64 is similar to the organization of StAR. However, as MLN64 never enters the mitochondria, the protease-resistant domain of MLN64 cannot be a mitochondrial pause-transfer sequence, as has been proposed for StAR.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Metastatic lymph node gene 64 protein; metastatic lymph node protein 64; MLN 64; Protein CAB1; Protein ES 64; Protein MLN 64; StAR-related lipid transfer (START) domain containing 3; StAR-related lipid transfer domain containing 3; StAR-related lipid transfer protein 3; StARD3; START domain containing 3; START domain-containing protein 3; steroidogenic acute regulatory protein related
基因别名: CAB1; Es64; MLN64; STARD3
UniProt ID: (Human) Q14849, (Mouse) Q61542
Entrez Gene ID: (Human) 10948, (Mouse) 59045, (Rat) 363675
