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Invitrogen
MMAF Monoclonal Antibody (A5G11)
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MMAF Antibody (MA5-42538) in ELISA
ELISA analysis of MMAF Monoclonal Antibody (Product # MA5-42538) with MMAF-ADC, MMAF-BSA, MMAE-BSA, DM1-ADC and BSA protein at 1 μg/mL overnight at 4°C. Then blocked with 1% BSA for 1 hour at 37°C, and incubated with the primary antibody for 1 hour at 25°C. MMAF Monoclonal Antibody can bind to MMAF-ADC or MMAF-BSA but not BSA or MMAE-BSA.
产品信息
MA5-42538
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
A5G11
抗原
MMAF coupled with OVA
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Product has been tested in direct ELISA
靶标信息
Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of the approved drug belantamab mafodotin in multiple myeloma and some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. In International Nonproprietary Names for MMAF-antibody-conjugates, the name mafodotin refers to MMAF plus its attachment structure to the antibody. Monomethyl auristatin F is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. It is linked to an antibody with high affinity to structures on cancer cells, causing MMAF to accumulate in such cells. MMAF is actually desmethyl-auristatin F; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin F itself.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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