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产品信息
PA5-96159
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 75-174 of human MMP14/MMP14/MT1-MMP (NP_0049861)
偶联物
形式
Liquid
浓度
0.55 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807961
产品详细信息
Positive Samples: THP-1, NCI-H460, Mouse liver; Cellular Location: Cytoplasm, Melanosome, Membrane, Single-pass type I membrane protein
Immunogen sequence: QVTGKADADT MKAMRRPRCG VPDKFGAEIK ANVRRKRYAI QGLKWQHNEI TFCIQNYTPK VGEYATYEAI RKAFRVWESA TPLRFREVPY AYIREGHEKQ
靶标信息
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EC 3.4.24.80; matrix metallo protease; matrix metallopeptidase 14 (membrane-inserted); matrix metalloproteinase 14 (membrane-inserted); matrix metalloproteinase 14 membrane-inserted; matrix metalloproteinase 14, membrane-inserted; Matrix metalloproteinase-14; membrane type 1 metalloprotease; membrane type 1-matrix metalloproteinase; Membrane type 1-MMP; Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase; MMP; MMP-14; MMP-X MT-MMP; MMP-X1; MMPs; MT-MMP; MT-MMP 1; MT-MMP MT1-MMP; MT1-MMP; MT1MMP; MTMMP1; type 1 matrix metalloprotease 14
基因别名: AI325305; MMP-14; MMP-X1; MMP14; MT-MMP; MT-MMP 1; MT-MMP-1; MT1-MMP; MT1MMP; Mtmmp; MTMMP1; sabe; WNCHRS
UniProt ID: (Human) P50281, (Mouse) P53690, (Rat) Q10739
Entrez Gene ID: (Human) 4323, (Mouse) 17387, (Rat) 81707
metalloendopeptidase activity
serine-type endopeptidase activity
integrin binding
calcium ion binding
protein binding
zinc ion binding
peptidase activator activity
transcription factor activity, sequence-specific DNA binding
peptidase activity
metallopeptidase activity
hydrolase activity
metal ion binding
metalloprotease
angiogenesis
ovarian follicle development
response to hypoxia
endothelial cell proliferation
endochondral ossification
proteolysis
response to oxidative stress
male gonad development
response to mechanical stimulus
response to hormone
positive regulation of myotube differentiation
positive regulation of peptidase activity
response to organic cyclic compound
extracellular matrix disassembly
positive regulation of cell growth
lung development
positive regulation of cell migration
collagen catabolic process
zymogen activation
endodermal cell differentiation
chondrocyte proliferation
astrocyte cell migration
response to estrogen
positive regulation of B cell differentiation
negative regulation of Notch signaling pathway
embryonic cranial skeleton morphogenesis
branching morphogenesis of an epithelial tube
tissue remodeling
negative regulation of focal adhesion assembly
craniofacial suture morphogenesis
ossification
regulation of transcription, DNA-templated
cell migration
bone development
